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Article

PDGF receptor mutations in human diseases.

Cellular and molecular life sciences : CMLS - 1 Apr 2021

Guérit Emilie, Arts Florence, Dachy Guillaume, Boulouadnine Boutaina, Demoulin Jean-Baptiste

Abstract excerpt

PDGFRA and PDGFRB are classical proto-oncogenes that encode receptor tyrosine kinases responding to platelet-derived growth factor (PDGF). PDGFRA mutations are found in gastrointestinal stromal tumors (GISTs), inflammatory fibroid polyps and gliomas, and PDGFRB mutations drive myofibroma development. In addition, chromosomal rearrangement of either gene causes myeloid neoplasms associated with hypereosinophilia....

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Eosinophilic Disorders and Syndromes
Gastrointestinal Neoplasms
Gastrointestinal Stromal Tumors
IgG4-Related and Inflammatory Diseases
Intestinal Polyps

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Receptors, Platelet-Derived Growth Factor

Tuberous Sclerosis Complex Research

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Identifiers

PMID: 33449152
DOI: 10.1007/s00018-020-03753-y
PMCID: PMC11072557

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