Article
Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice.
Blood - 1 Apr 2001
Kaminski W E, Lindahl P, Lin N L, Broudy V C, Crosby J R, Hellström M, Swolin B, Bowen-Pope D F, Martin P J, Ross R, Betsholtz C, Raines E W
Abstract excerpt
Platelet-derived growth factor (PDGF)-B and PDGF beta-receptor (PDGFR beta) deficiency in mice is embryonic lethal and results in cardiovascular, renal, placental, and hematologic disorders. The hematologic disorders are described, and a correlation with hepatic hypocellularity is demonstrated. To explore possible causes, the colony-forming activity of fetal liver cells in vitro was assessed, and hematopoietic...
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