Article
An activating mutation in the PDGF receptor alpha results in embryonic lethality caused by malformation of the vascular system.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 May 2009
Kurth Patricia, Moenning Anne, Jäger Richard, Beine Gaby, Schorle Hubert
Abstract excerpt
Platelet-derived growth factors (PDGF) and their receptors control cell proliferation, survival, and migration. To test the influence of an oncogenic mutation to embryonic development, a transgenic mouse line expressing PDGFRalpha (D842V) was established and analyzed. Most of the embryos die on embryonic day 12.5 due to massive hemorrhages in the trunk. In mesenchymal cells of mutant animals, proliferation is...
Topics
- Animals
- Aorta
- Embryo Loss
- Embryo, Mammalian
- Embryonic Development
- Mice
- Mice, Transgenic
- Muscle, Smooth, Vascular
- Mutation
- Neural Tube Defects
- Receptor, Platelet-Derived Growth Factor alpha