Article
A gain of function mutation in the activation loop of platelet-derived growth factor beta-receptor deregulates its kinase activity.
The Journal of biological chemistry - 8 Oct 2004
Chiara Federica, Goumans Marie-José, Forsberg Henrik, Ahgrén Aive, Rasola Andrea, Aspenström Pontus, Wernstedt Christer, Hellberg Carina, Heldin Carl-Henrik, Heuchel Rainer
Abstract excerpt
The platelet-derived growth factor receptors (PDGFRs) are receptor tyrosine kinases implicated in multiple aspects of cell growth, differentiation, and survival. Recently, a gain of function mutation in the activation loop of the human PDGFRalpha has been found in patients with gastrointestinal stromal tumors. Here we show that a mutation in the corresponding codon in the activation loop of the murine PDGFRbeta,...
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