Article
Variation in the gene coding for the M5 muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adults.
BMC genetics - 3 Jul 2007
Anney Richard J L, Lotfi-Miri Mehrnoush, Olsson Craig A, Reid Sophie C, Hemphill Sheryl A, Patton George C
Abstract excerpt
BACKGROUND: The mesolimbic structures of the brain are important in the anticipation and perception of reward. Moreover, many drugs of addiction elicit their response in these structures. The M5 muscarinic receptor (M5R) is expressed in dopamine-containing neurones of the substantia nigra pars co...
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