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Article

Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Mar 2010

Mobascher A, Rujescu D, Mittelstraß K, Giegling I, Lamina C, Nitz B, Brenner H, Fehr C, Breitling L P, Gallinat J, Rothenbacher D, Raum E, Müller H, Ruppert A, Hartmann A M, Möller H J, Gal A, Gieger Ch, Wichmann H E, Illig T, Dahmen N, Winterer G

Abstract excerpt

Genetic factors contribute to the overall risk of developing nicotine addiction, which is the major cause of preventable deaths in western countries. However, knowledge regarding specific polymorphisms influencing smoking phenotypes remains scarce. In the present study we provide evidence that a...

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Source

Identifiers

PMID: 19644963
DOI: 10.1002/ajmg.b.31011

Genes

CHRM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19644963-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Association of a variant in the muscarinic acetylcholine receptor 2 gene (CHRM2) with nicotine addiction.PMID 19644963Read ↗

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The nicotinic acetylcholine receptor CHRNA5/A3/B4 gene cluster: dual role in nicotine addiction and lung cancer.Semantic proximity Read ↗

Variation in the gene coding for the M5 muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adults.Semantic proximity Read ↗

Association of nicotinic acetylcholine receptor subunit alpha 4 polymorphisms with nicotine dependence in 5500 Germans.Semantic proximity Read ↗

Impact of genetic variability in nicotinic acetylcholine receptors on nicotine addiction and smoking cessation treatment.Semantic proximity Read ↗

CHRM2 gene predisposes to alcohol dependence, drug dependence and affective disorders: results from an extended case-control structured association study.Semantic proximity Read ↗

Genetic variability in nicotinic acetylcholine receptors and nicotine addiction: converging evidence from human and animal research.Semantic proximity Read ↗

Haplotypes of four novel single nucleotide polymorphisms in the nicotinic acetylcholine receptor beta2-subunit (CHRNB2) gene show no association with smoking initiation or nicotine dependence.Semantic proximity Read ↗

Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions.Semantic proximity Read ↗

Gene-based analysis suggests association of the nicotinic acetylcholine receptor beta1 subunit (CHRNB1) and M1 muscarinic acetylcholine receptor (CHRM1) with vulnerability for nicotine dependence.Semantic proximity Read ↗

Association of CHRM2 polymorphisms with severity of alcohol dependence.Semantic proximity Read ↗

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