Article
Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 1997
Tian B, Meng Q C, Chen Y F, Krege J H, Smithies O, Oparil S
Abstract excerpt
We studied cardiovascular phenotypes in wild-type (+/+), heterozygous (+/-), and homozygous mutant (-/-) mice for an insertional inactivation of the angiotensin-converting enzyme (ACE) gene (Ace in mice, ACE in humans). Compared with +/+ mice, baseline mean arterial pressure was not significantly altered in +/- mice but was reduced by 51+/-4 mm Hg in -/- mice. Although the pressor response to injected angiotensin...
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