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Article

The AT1A receptor "gain-of-function" mutant N111S/delta329 is both constitutively active and hyperreactive to angiotensin II.

American journal of physiology. Endocrinology and metabolism - 1 May 2006

Billet Sandrine, Bardin Sabine, Tacine Rachida, Clauser Eric, Conchon Sophie

Abstract excerpt

The renin-angiotensin-aldosterone system (RAAS) is central to cardiovascular and renal physiology. However, there is no animal model in which the activation of the RAAS only reflects the activation of the angiotensin II (ANG II) AT1 receptor. As a first step to developing such a model, we characterized a gain-of-function mutant of the mouse AT1A receptor. This mutant carries two mutations: N111S predicted to...

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PMID: 16332920
DOI: 10.1152/ajpendo.00458.2005

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ANG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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