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Article

Physiological impact of increased expression of the AT1 angiotensin receptor.

Hypertension (Dallas, Tex. : 1979) - 1 Oct 2003

Le Thu H, Kim Hyung-Suk, Allen Andrew M, Spurney Robert F, Smithies Oliver, Coffman Thomas M

Abstract excerpt

To test the effect of increased AT1 receptor expression on blood pressure, we used gene targeting to generate mouse lines with a tandem duplication of the AT1A receptor gene locus (Agtr1a) along with >10 kb of 5' flanking DNA. By successive breeding, we generated mice with 3 and 4 copies of the Agtr1a gene locus on an inbred 129/Sv background. AT1A mRNA expression and AT1-specific binding of 125I-angiotensin II...

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Identifiers

PMID: 12963678
DOI: 10.1161/01.HYP.0000092000.07559.57

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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