Article
Association of Trp53 polymorphic variants at codon 72 with nonsyndromic mental retardation.
Neuroscience research - 1 Sept 2007
Saccucci P, Galasso C, Rizzo R, Gagliano A, Refice F, Lalli C, Verrotti A, Gloria-Bottini F, Curatolo P
Abstract excerpt
Mental retardation is the most common developmental disability affecting 2-3% of the population, a consequence of a wide range of genetic or nongenetic etiologic factors. The cause of mental retardation remains unknown in about 50% of cases. Trp53 (transformation related protein 53, also known as p53) is a tumor suppressor gene that activates the expression of genes involved in inducing growth arrest of cells in...
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