Article
Prognostic value of the TP53 Arg72Pro single-nucleotide polymorphism and susceptibility to medulloblastoma in a cohort of Brazilian patients.
Journal of neuro-oncology - 1 Oct 2012
Carvalho Raimundo M, Pinto Giovanny R, Yoshioka France K N, Lima Patrícia D L, Souza Carolina R T, Guimarães Adriana C, Lamarão Letícia M, Rey Juan A, Burbano Rommel R
Abstract excerpt
Medulloblastoma is a highly cellular malignant embryonal neoplasm, being the most common malignant pediatric brain tumor, accounting for 20-25 % of pediatric central nervous system tumors. To investigate the effect of the TP53 Arg72Pro single-nucleotide polymorphism (SNP) on clinicopathological and phenotypic parameters, we performed a case-controlled study of 122 patients and 122 healthy controls from Brazil. No...
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