Article
Analysis of polymorphisms at the tumor suppressor gene p53 (TP53) in contributing to the risk for schizophrenia and its associated neurocognitive deficits.
Neuroscience letters - 3 Jun 2004
Papiol Sergi, Arias Bárbara, Barrantes-Vidal Neus, Guitart Marc, Salgado Purificación, Catalán Rosa, Fañanás Lourdes
Abstract excerpt
Owing to the role of the nuclear phosphoprotein p53 in the regulation of neurodegeneration and neurodevelopmental processes, some authors have suggested TP53 as a candidate gene for schizophrenia and/or the neurocognitive deficits commonly observed in these patients. In the present study we have analyzed two polymorphisms (Pro72Arg and 16 bp insertion) located on the TP53 gene in order to investigate their role...
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