Article
Is p53 polymorphism maintained by natural selection?
Human heredity - 1 Jan 2000
Beckman G, Birgander R, Själander A, Saha N, Holmberg P A, Kivelä A, Beckman L
Abstract excerpt
We present here a new interesting feature of the human tumor suppressor gene p53: a very pronounced ethnic and clinal variation of polymorphic codon 72 alleles. The frequency of the A1 (Pro) allele showed a north-south cline from 17% in Swedish Saamis to 63% in African Blacks (Nigerians), and the...
Topics
- Alleles
- Base Sequence
- DNA Primers
- Gene Frequency
- Genes, p53
- Humans
- Molecular Sequence Data
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Selection, Genetic