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Article

Is p53 polymorphism maintained by natural selection?

Human heredity - 1 Jan 2000

Beckman G, Birgander R, Själander A, Saha N, Holmberg P A, Kivelä A, Beckman L

Abstract excerpt

We present here a new interesting feature of the human tumor suppressor gene p53: a very pronounced ethnic and clinal variation of polymorphic codon 72 alleles. The frequency of the A1 (Pro) allele showed a north-south cline from 17% in Swedish Saamis to 63% in African Blacks (Nigerians), and there was a significant (p < 0.001) correlation (r = 0.95) between the A2 frequency and latitude. In the Finnish and...

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Identifiers

PMID: 7927355
DOI: 10.1159/000154228

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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