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Article

Recurrent pregnancy failure is associated with a polymorphism in the p53 tumour suppressor gene.

Human reproduction (Oxford, England) - 1 Apr 2005

Pietrowski Detlef, Bettendorf Hertha, Riener Eva-Katrin, Keck Christoph, Hefler Lukas A, Huber Johannes C, Tempfer Clemens

Abstract excerpt

BACKGROUND: The p53 tumour suppressor gene is a well-known factor regulating apoptosis in a wide variety of cells and tissues. Alterations in the p53 gene are among the most common genetic changes in human cancers. In addition, recent data provide evidence that p53 plays a critical role in mediating pregnancy by regulating steroid hormone activation. In idiopathic recurrent miscarriages (IRM), causes and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15608028
DOI: 10.1093/humrep/deh696

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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