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Association between TP53 gene Arg72Pro polymorphism and Wilms’ tumor risk in a Chinese population

1 Feb 2017

Abstract excerpt

Abstract: Wilms’ tumor is one of the most prevalent pediatric malignancies, ranking fourth in childhood cancer worldwide. TP53 is a critical tumor suppressor gene, which encodes a 53 kDa protein, p53. The p53 functions to protect against cancer by regulating cell cycle and apoptosis and maintaining DNA integrity. TP53 gene is highly polymorphic. Several TP53 gene polymorphisms have been considered to be...

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PMID: 28260929
DOI: 10.2147/ott.s131014

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