Article
Prognostic value of TP53 Pro47Ser and Arg72Pro single nucleotide polymorphisms and the susceptibility to gliomas in individuals from Southeast Brazil.
Genetics and molecular research : GMR - 26 Feb 2008
Pinto G R, Yoshioka F K N, Silva R L L, Clara C A, Santos M J, Almeida J R W, Burbano R R, Rey J A, Casartelli C
Abstract excerpt
The TP53 tumor suppressor gene codifies a protein responsible for preventing cells with genetic damage from growing and dividing by blocking cell growth or apoptosis pathways. A common single nucleotide polymorphism (SNP) in TP53 codon 72 (Arg72Pro) induces a 15-fold decrease of apoptosis-inducing ability and has been associated with susceptibility to human cancers. Recently, another TP53 SNP at codon 47...
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