Article
No association of the p53 codon 72 polymorphism with malaria in Ghanaian primiparae and Rwandan children.
The American journal of tropical medicine and hygiene - 1 Jun 2014
Gai Prabhanjan P, Meese Stefanie, Bedu-Addo George, Gahutu Jean Bosco, Mockenhaupt Frank P
Abstract excerpt
The p53 protein is a key cell-signaling mediator integrating host responses to various types of stress. A common polymorphism of the encoding TP53 gene (codon 72, Pro > Arg, rs1042522) is associated with susceptibility to virus-related and other cancers. The p53 has also been shown to be central for successful Plasmodium liver stage infection. We examined whether the polymorphism is associated with P. falciparum...
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