Article
The codon 72 polymorphism of p53 influences cell fate following nutrient deprivation.
Cancer biology & therapy - 3 Jul 2017
Kung Che-Pei, Liu Qin, Murphy Maureen E
Abstract excerpt
The TP53 gene is distinguished as the most frequently mutated gene in cancer. Unlike most cancer-relevant genes, the TP53 gene is also distinguished by the existence of coding region polymorphisms that alter p53 sequence, and in some cases, also alter p53 function. A common coding region variant at amino acid 72 of p53 encodes either proline (P72) or arginine (R72). P72 is the ancestral variant and is most common...
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