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Article

The zebra fish cassiopeia mutant reveals that SIL is required for mitotic spindle organization.

Molecular and cellular biology - 1 Aug 2007

Pfaff Kathleen L, Straub Christian T, Chiang Ken, Bear Daniel M, Zhou Yi, Zon Leonard I

Abstract excerpt

A critical step in cell division is formation of the mitotic spindle, which is a bipolar array of microtubules that mediates chromosome separation. Here, we report that the SCL-interrupting locus (SIL), a vertebrate-specific cytosolic protein, is necessary for proper mitotic spindle organization in zebrafish and human cells. A homozygous lethal zebrafish mutant, cassiopeia (csp), was identified by a genetic...

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Identifiers

PMID: 17576815
DOI: 10.1128/MCB.00175-07
PMCID: PMC1952118

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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