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Article

A mutation in separase causes genome instability and increased susceptibility to epithelial cancer.

Genes & development - 1 Jan 2007

Shepard Jennifer L, Amatruda James F, Finkelstein David, Ziai James, Finley K Rose, Stern Howard M, Chiang Ken, Hersey Candace, Barut Bruce, Freeman Jennifer L, Lee Charles, Glickman Jonathan N, Kutok Jeffery L, Aster Jon C, Zon Leonard I

Abstract excerpt

Proper chromosome segregation is essential for maintenance of genomic integrity and instability resulting from failure of this process may contribute to cancer. Here, we demonstrate that a mutation in the mitotic regulator separase is responsible for the cell cycle defects seen in the zebrafish mutant, cease&desist (cds). Analysis of cds homozygous mutant embryos reveals high levels of polyploidy and aneuploidy,...

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Identifiers

PMID: 17210788
DOI: 10.1101/gad.1470407
PMCID: PMC1759900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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