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Article

Interruption of cenph causes mitotic failure and embryonic death, and its haploinsufficiency suppresses cancer in zebrafish.

The Journal of biological chemistry - 3 Sept 2010

Zhao Xinyi, Zhao Long, Tian Tian, Zhang Yu, Tong Jingyuan, Zheng Xiaofeng, Meng Anming

Abstract excerpt

Kinetochore proteins associate with centromeric DNA and spindle microtubules and play essential roles in chromosome segregation during mitosis. In this study, we uncovered a zebrafish mutant, stagnant and curly (stac), that carries the Tol2 transposon element inserted at the kinetochore protein H (cenph) locus. Mutant embryos exhibit discernible cell death as early as 20 hours postfertilization, extensive...

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Identifiers

PMID: 20573960
DOI: 10.1074/jbc.M110.136077
PMCID: PMC2934659

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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