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Article

LIS1 controls mitosis and mitotic spindle organization via the LIS1-NDEL1-dynein complex.

Human molecular genetics - 15 Jan 2014

Moon Hyang Mi, Youn Yong Ha, Pemble Hayley, Yingling Jessica, Wittmann Torsten, Wynshaw-Boris Anthony

Abstract excerpt

Heterozygous LIS1 mutations are responsible for the human neuronal migration disorder lissencephaly. Mitotic functions of LIS1 have been suggested from many organisms throughout evolution. However, the cellular functions of LIS1 at distinct intracellular compartments such as the centrosome and the cell cortex have not been well defined especially during mitotic cell division. Here, we used detailed cellular...

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Source

Open in PubMed Open full text

Identifiers

PMID: 24030547
DOI: 10.1093/hmg/ddt436
PMCID: PMC3869364

Genes

NDEL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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