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Oocyte Spindle Proteomics Analysis Leading to Rescue of Chromosome Congression Defects in Cloned Embryos

30 Sept 2010

Abstract excerpt

Embryos produced by somatic cell nuclear transfer (SCNT) display low term developmental potential. This is associated with deficiencies in spindle composition prior to activation and at early mitotic divisions, including failure to assemble certain proteins on the spindle. The protein-deficient spindles are accompanied by chromosome congression defects prior to activation and during the first mitotic divisions of...

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PMID: 20883044
DOI: 10.1021/pr100827j

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