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Article

Genes required for mitotic spindle assembly in Drosophila S2 cells.

Science (New York, N.Y.) - 20 Apr 2007

Goshima Gohta, Wollman Roy, Goodwin Sarah S, Zhang Nan, Scholey Jonathan M, Vale Ronald D, Stuurman Nico

Abstract excerpt

The formation of a metaphase spindle, a bipolar microtubule array with centrally aligned chromosomes, is a prerequisite for the faithful segregation of a cell's genetic material. Using a full-genome RNA interference screen of Drosophila S2 cells, we identified about 200 genes that contribute to spindle assembly, more than half of which were unexpected. The screen, in combination with a variety of secondary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 17412918
DOI: 10.1126/science.1141314
PMCID: PMC2837481

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