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Article

Acentriolar mitosis activates a p53-dependent apoptosis pathway in the mouse embryo.

Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 2014

Bazzi Hisham, Anderson Kathryn V

Abstract excerpt

Centrosomes are the microtubule-organizing centers of animal cells that organize interphase microtubules and mitotic spindles. Centrioles are the microtubule-based structures that organize centrosomes, and a defined set of proteins, including spindle assembly defective-4 (SAS4) (CPAP/CENPJ), is required for centriole biogenesis. The biological functions of centrioles and centrosomes vary among animals, and the...

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Identifiers

PMID: 24706806
DOI: 10.1073/pnas.1400568111
PMCID: PMC3992648

Genes

CPAP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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