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Article

Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1genes

1 Dec 2014

Abstract excerpt

BACKGROUND: Despite being a fundamental biological problem the control of body size and proportions during development remains poorly understood, although it is accepted that the insulin-like growth factor (IGF) pathway has a central role in growth regulation, probably in all animals. The involvement of imprinted genes has also attracted much attention, not least because two of the earliest discovered were shown...

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PMID: 25551289
DOI: 10.1186/s12915-014-0099-8

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Antagonistic roles in fetal development and adult physiology for the oppositely imprinted Grb10 and Dlk1genesPMID 25551289Read ↗

Imprinted <i>Grb10</i> , encoding growth factor receptor bound protein 10, regulates fetal growth independently of the insulin-like growth factor type 1 receptor ( <i>Igf1r</i> ) and insulin receptor ( <i>Insr</i> ) genesSemantic proximity Read ↗

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IGF2: Development, Genetic and Epigenetic AbnormalitiesSemantic proximity Read ↗

The placental imprinted DLK1-DIO3 domain: a new link to prenatal and postnatal growth in humansSemantic proximity Read ↗

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Imprinted <i>Dlk1</i> dosage as a size determinant of the mammalian pituitary glandSemantic proximity Read ↗

Fetus-derived DLK1 is required for maternal metabolic adaptations to pregnancy and is associated with fetal growth restrictionSemantic proximity Read ↗

Restricted co-expression of Dlk1 and the reciprocally imprinted non-coding RNA, Gtl2: implications for cis-acting control.Semantic proximity Read ↗

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