Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.

doi:10.1074/jbc.M304599200

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Article

Growth factor receptor-binding protein 10 (Grb10) as a partner of phosphatidylinositol 3-kinase in metabolic insulin action.

The Journal of biological chemistry - 10 Oct 2003

Deng Youping, Bhattacharya Sujoy, Swamy O Rama, Tandon Ruchi, Wang Yong, Janda Robert, Riedel Heimo

Abstract excerpt

The regulation of the metabolic insulin response by mouse growth factor receptor-binding protein 10 (Grb10) has been addressed in this report. We find mouse Grb10 to be a critical component of the insulin receptor (IR) signaling complex that provides a functional link between IR and p85 phosphatidylinositol (PI) 3-kinase and regulates PI 3-kinase activity. This regulatory mechanism parallels the established link...

Topics

3T3 Cells
Adipocytes
Amino Acids
Animals
Base Sequence
Cell Differentiation
Cell Line
DNA, Complementary
GRB10 Adaptor Protein
Glucose
Glycogen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Insulin

Insulin Receptor Substrate Proteins

Intracellular Signaling Peptides and Proteins

Lipids

Mice

Mutation

Source

Open in PubMed

Identifiers

PMID: 12783867
DOI: 10.1074/jbc.M304599200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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