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De-silencing Grb10 contributes to acute ER stress-induced steatosis in mouse liver

19 Mar 2018

Abstract excerpt

The growth factor receptor bound protein GRB10 is an imprinted gene product and a key negative regulator of the insulin, IGF1 and mTORC1 signaling pathways. GRB10 is highly expressed in mouse fetal liver but almost completely silenced in adult mice, suggesting a potential detrimental role of this protein in adult liver function. Here we show that the Grb10 gene could be reactivated in adult mouse liver by acute...

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PMID: 29555819
DOI: 10.1530/jme-18-0018

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