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Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration

1 Nov 2016

Abstract excerpt

Imprinted genes are differentially expressed by adult stem cells, but their functions in regulating adult stem cell fate are incompletely understood. Here we show that growth factor receptor-bound protein 10 ( Grb10 ), an imprinted gene, regulates hematopoietic stem cell (HSC) self-renewal and regeneration. Deletion of the maternal allele of Grb10 in mice ( Grb10 m/+ mice) substantially increased HSC long-term...

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PMID: 27806297
DOI: 10.1016/j.celrep.2016.10.025

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