Article
The adapter protein Grb10 associates preferentially with the insulin receptor as compared with the IGF-I receptor in mouse fibroblasts.
The Journal of clinical investigation - 1 Mar 1997
Laviola L, Giorgino F, Chow J C, Baquero J A, Hansen H, Ooi J, Zhu J, Riedel H, Smith R J
Abstract excerpt
To identify receptor-associated proteins that may contribute to the specificity of insulin and IGF-I signaling responses, a mouse embryo library was screened using the yeast two-hybrid system. Multiple receptor-interactive clones encoding the SH2 domain of the adapter protein Grb10 were isolated....
Topics
- Animals
- Blotting, Northern
- Cloning, Molecular
- DNA Primers
- DNA, Complementary
- Electrophoresis, Agar Gel
- Electrophoresis, Polyacrylamide Gel
- Fibroblasts
- GRB10 Adaptor Protein
- Gene Expression Regulation
- Gene Library