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Article

Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells.

Journal of molecular biology - 3 Aug 2007

Arnould Sylvain, Perez Christophe, Cabaniols Jean-Pierre, Smith Julianne, Gouble Agnès, Grizot Sylvestre, Epinat Jean-Charles, Duclert Aymeric, Duchateau Philippe, Pâques Frédéric

Abstract excerpt

Meganucleases are sequence-specific endonucleases which recognize large (>12 bp) target sites in living cells and can stimulate homologous gene targeting by a 1000-fold factor at the cleaved locus. We have recently described a combinatorial approach to redesign the I-CreI meganuclease DNA-binding interface, in order to target chosen sequences. However, engineering was limited to the protein regions shown to...

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Identifiers

PMID: 17561112
DOI: 10.1016/j.jmb.2007.04.079

Genes

XPC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells.PMID 17561112Read ↗

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