Article

Generation and characterization of CRISPR-Cas9-Mediated <i>XPC</i> Gene Knockout in Human Skin Cells

2024-01-25

Abstract excerpt

Xeroderma pigmentosum group C (XPC) is a versatile protein, crucial for sensing DNA damage in the global genome nucleotide excision repair (GG-NER) pathway. This pathway is vital for mammalian cells, acting as their essential approach for repairing DNA lesions stemming from interactions with environmental factors, such as exposure to ultraviolet (UV) radiation from the sun. Loss-of-function mutations in the XPC g...

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Literature Corpus work: 682da5e9-3302-5a3a-b078-17e8598b8678
DOI: 10.1101/2024.01.25.577199

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