Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted gene therapy of xeroderma pigmentosum cells using meganuclease and TALEN™.

PloS one - 1 Jan 2013

Dupuy Aurélie, Valton Julien, Leduc Sophie, Armier Jacques, Galetto Roman, Gouble Agnès, Lebuhotel Céline, Stary Anne, Pâques Frédéric, Duchateau Philippe, Sarasin Alain, Daboussi Fayza

Abstract excerpt

Xeroderma pigmentosum group C (XP-C) is a rare human syndrome characterized by hypersensitivity to UV light and a dramatic predisposition to skin neoplasms. XP-C cells are deficient in the nucleotide excision repair (NER) pathway, a complex process involved in the recognition and removal of DNA lesions. Several XPC mutations have been described, including a founder mutation in North African patients involving the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deoxyribonucleases
Share to DNA Cleavage

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Repair

Share to Epigenesis, Genetic

Share to Genetic Therapy

Share to Mutagenesis

Share to Protein Engineering

Share to Xeroderma Pigmentosum

Source

Open in PubMed Open full text

Identifiers

PMID: 24236034
DOI: 10.1371/journal.pone.0078678
PMCID: PMC3827243

Genes

XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted gene therapy of xeroderma pigmentosum cells using meganuclease and TALEN™.PMID 24236034Read ↗

Engineered I-CreI derivatives cleaving sequences from the human XPC gene can induce highly efficient gene correction in mammalian cells.Semantic proximity Read ↗

Generation and characterization of CRISPR-Cas9-Mediated <i>XPC</i> Gene Knockout in Human Skin CellsSemantic proximity Read ↗

Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC.Semantic proximity Read ↗

Molecular genetics of Xeroderma pigmentosum variant.Semantic proximity Read ↗

Therapeutic repair of mutated nucleic acid sequences.Semantic proximity Read ↗

Efficient repair of cyclobutane pyrimidine dimers at mutational hot spots is restored in complemented Xeroderma pigmentosum group C and trichothiodystrophy/xeroderma pigmentosum group D cells.Semantic proximity Read ↗

Characterization of molecular defects in xeroderma pigmentosum group C.Semantic proximity Read ↗

Targeted gene correction: a new strategy for molecular medicine.Semantic proximity Read ↗

Retrovirus-mediated DNA repair gene transfer into xeroderma pigmentosum cells: perspectives for a gene therapy.Semantic proximity Read ↗

Identification of four novel XPC mutations in two xeroderma pigmentosum complementation group C patients and functional study of XPC Q320X mutant.Semantic proximity Read ↗

Conserved Residues of Human XPG Protein Important for Nuclease Activity and Function in Nucleotide Excision RepairSemantic proximity Read ↗

Characterization of defective nucleotide excision repair in XPC mutant mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.