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Article

A functional prodynorphin promoter polymorphism and opioid dependence.

Psychiatric genetics - 1 Dec 2005

Ray Riju, Doyle Glenn A, Crowley James J, Buono Russell J, Oslin David W, Patkar Ashwin A, Mannelli Paolo, DeMaria Peter A, O'Brien Charles P, Berrettini Wade H

Abstract excerpt

OBJECTIVES: The prodynorphin gene (PDYN) promoter has a repeat polymorphism that is functionally important in association with substance abuse. We examined this polymorphism for association in our sample of 168 opioid-dependent patients and 122 ethnically and geographically matched controls. METHODS: Patients were selected from university-affiliated residential and non-residential addiction treatment programs in...

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Source

Identifiers

PMID: 16314761
DOI: 10.1097/00041444-200512000-00013

Genes

PDYN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional prodynorphin promoter polymorphism and opioid dependence.PMID 16314761Read ↗

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An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression.Semantic proximity Read ↗

Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence.Semantic proximity Read ↗

Genetic association analyses of PDYN polymorphisms with heroin and cocaine addiction.Semantic proximity Read ↗

Association between VNTR polymorphism in promoter region of prodynorphin (PDYN) gene and heroin dependence.Semantic proximity Read ↗

Association between heroin dependence and prodynorphin gene polymorphisms.Semantic proximity Read ↗

Prodynorphin promoter SNP associated with alcohol dependence forms noncanonical AP-1 binding site that may influence gene expression in human brain.Semantic proximity Read ↗

Prodynorphin CpG-SNPs associated with alcohol dependence: elevated methylation in the brain of human alcoholics.Semantic proximity Read ↗

Genetic variation and epigenetic modification of the prodynorphin gene in peripheral blood cells in alcoholism.Semantic proximity Read ↗

Multiple Functional Variants in cis Modulate PDYN Expression.Semantic proximity Read ↗

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