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Article

Pro-opiomelanocortin gene variation related to alcohol or drug dependence: evidence and replications across family- and population-based studies.

Biological psychiatry - 15 Jul 2009

Zhang Huiping, Kranzler Henry R, Weiss Roger D, Luo Xingguang, Brady Kathleen T, Anton Raymond F, Farrer Lindsay A, Gelernter Joel

Abstract excerpt

BACKGROUND: Opioidergic neurotransmission is critical in many, possibly all, forms of substance dependence. Several opioid-system genes have been shown to be associated with substance dependence disorders. The pro-opiomelanocortin gene (POMC) encodes several peptides important for endogenous opioidergic neurotransmission. We tested whether POMC genetic variation affects risk for substance dependence. METHODS:...

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Identifiers

PMID: 19217079
DOI: 10.1016/j.biopsych.2008.12.021
PMCID: PMC2896237

Genes

POMC

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