Article
Confirmation of the association between a polymorphism in the promoter region of the prodynorphin gene and cocaine dependence.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Nov 2005
Dahl John P, Weller Andrew E, Kampman Kyle M, Oslin David W, Lohoff Falk W, Ferraro Thomas N, O'Brien Charles P, Berrettini Wade H
Abstract excerpt
The endogenous opioid system has been shown to have a role in the biological processes involved in addiction to numerous drugs of abuse including cocaine. It has recently been reported that the variable nucleotide tandem repeat (VNTR) polymorphism in the 5' promoter region of the prodynorphin gene, which encodes the precursor for three endogenous opioid peptides, is associated with the cocaine dependent...
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