Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

UNC-46 is required for trafficking of the vesicular GABA transporter.

Nature neuroscience - 1 Jul 2007

Schuske Kim, Palfreyman Mark T, Watanabe Shigeki, Jorgensen Erik M

Abstract excerpt

Mutations in unc-46 in Caenorhabditis elegans cause defects in all behaviors that are mediated by GABA. Here we show that UNC-46 is a sorting factor that localizes the vesicular GABA transporter to synaptic vesicles. The UNC-46 protein is related to the LAMP (lysosomal associated membrane protein) family of proteins and is localized at synapses. In unc-46 mutants, the vesicular transporter is not found...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Motor Activity
Share to Synaptic Vesicles
Share to Caenorhabditis elegans Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Electrophysiology

Share to Endoplasmic Reticulum

Share to gamma-Aminobutyric Acid

Share to Golgi Apparatus

Share to Lysosomal Membrane Proteins

Source

Identifiers

PMID: 17558401
DOI: 10.1038/nn1920

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

UNC-46 is required for trafficking of the vesicular GABA transporter.PMID 17558401Read ↗

The deubiquitinating enzyme USP-46 negatively regulates the degradation of glutamate receptors to control their abundance in the ventral nerve cord of Caenorhabditis elegans.Semantic proximity Read ↗

Identification and characterization of the vesicular GABA transporter.Semantic proximity Read ↗

Regulation of nicotinic receptor trafficking by the transmembrane Golgi protein UNC-50.Semantic proximity Read ↗

The JIP3 scaffold protein UNC-16 regulates RAB-5 dependent membrane trafficking at C. elegans synapses.Semantic proximity Read ↗

Auxin-inducible degradation of UNC-116 in <i>C. elegans</i> inhibits bidirectional dense core vesicle transport and worm locomotion on different timescalesSemantic proximity Read ↗

UNC-41/stonin functions with AP2 to recycle synaptic vesicles in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans.Semantic proximity Read ↗

Mutations in synaptojanin disrupt synaptic vesicle recycling.Semantic proximity Read ↗

Defects in synaptic vesicle docking in unc-18 mutants.Semantic proximity Read ↗

Kinesin-1 regulates synaptic strength by mediating the delivery, removal, and redistribution of AMPA receptors.Semantic proximity Read ↗

UNC-108/Rab2 regulates postendocytic trafficking in Caenorhabditis elegans.Semantic proximity Read ↗

UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.