Article
UNC-16, a JNK-signaling scaffold protein, regulates vesicle transport in C. elegans.
Neuron - 6 Dec 2001
Byrd D T, Kawasaki M, Walcoff M, Hisamoto N, Matsumoto K, Jin Y
Abstract excerpt
Transport of synaptic components is a regulated process. Loss-of-function mutations in the C. elegans unc-16 gene result in the mislocalization of synaptic vesicle and glutamate receptor markers. unc-16 encodes a homolog of mouse JSAP1/JIP3 and Drosophila Sunday Driver. Like JSAP1/JIP3, UNC-16 physically interacts with JNK and JNK kinases. Deletion mutations in Caenorhabditis elegans JNK and JNK kinases result in...
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