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Article

Defects in synaptic vesicle docking in unc-18 mutants.

Nature neuroscience - 1 Oct 2003

Weimer Robby M, Richmond Janet E, Davis Warren S, Hadwiger Gayla, Nonet Michael L, Jorgensen Erik M

Abstract excerpt

Sec1-related proteins function in most, if not all, membrane trafficking pathways in eukaryotic cells. The Sec1-related protein required in neurons for synaptic vesicle exocytosis is UNC-18. Several models for UNC-18 function during vesicle exocytosis are under consideration. We have tested these models by characterizing unc-18 mutants of the nematode Caenorhabditis elegans. In the absence of UNC-18, the size of...

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Identifiers

PMID: 12973353
DOI: 10.1038/nn1118
PMCID: PMC3874415

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Defects in synaptic vesicle docking in unc-18 mutants.PMID 12973353Read ↗

UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.Semantic proximity Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

Binding of UNC-18 to the N-terminus of syntaxin is essential for neurotransmission in Caenorhabditis elegans.Semantic proximity Read ↗

Expression and function of Caenorhabditis elegans UNCP-18, a paralog of the SM protein UNC-18.Semantic proximity Read ↗

UNC-11, a Caenorhabditis elegans AP180 homologue, regulates the size and protein composition of synaptic vesicles.Semantic proximity Read ↗

UNC-13 is required for synaptic vesicle fusion in C. elegans.Semantic proximity Read ↗

UNC-13 interaction with syntaxin is required for synaptic transmission.Semantic proximity Read ↗

The JIP3 scaffold protein UNC-16 regulates RAB-5 dependent membrane trafficking at C. elegans synapses.Semantic proximity Read ↗

Munc18-1 regulates early and late stages of exocytosis via syntaxin-independent protein interactions.Semantic proximity Read ↗

Open syntaxin overcomes synaptic transmission defects in diverse <i>C. elegans</i> exocytosis mutantsSemantic proximity Read ↗

Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.Semantic proximity Read ↗

Open syntaxin overcomes exocytosis defects of diverse mutants in C. elegans.Semantic proximity Read ↗

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