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Article

UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.

Molecular biology of the cell - 1 Sept 2008

McEwen Jason M, Kaplan Joshua M

Abstract excerpt

The SM protein UNC-18 has been proposed to regulate several aspects of secretion, including synaptic vesicle docking, priming, and fusion. Here, we show that UNC-18 has a chaperone function in neurons, promoting anterograde transport of the plasma membrane soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein Syntaxin-1. In unc-18 mutants, UNC-64 (Caenorhabditis elegans Syntaxin-1)...

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Identifiers

PMID: 18596236
DOI: 10.1091/mbc.e08-02-0160
PMCID: PMC2526711

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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UNC-18 promotes both the anterograde trafficking and synaptic function of syntaxin.PMID 18596236Read ↗

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Defects in synaptic vesicle docking in unc-18 mutants.Semantic proximity Read ↗

Regulation of the UNC-18-Caenorhabditis elegans syntaxin complex by UNC-13.Semantic proximity Read ↗

UNC-18 and Tomosyn Antagonistically Control Synaptic Vesicle Priming Downstream of UNC-13 in Caenorhabditis elegans.Semantic proximity Read ↗

Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin.Semantic proximity Read ↗

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Expression and function of Caenorhabditis elegans UNCP-18, a paralog of the SM protein UNC-18.Semantic proximity Read ↗

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Functional properties of the unc-64 gene encoding a Caenorhabditis elegans syntaxin.Semantic proximity Read ↗

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