Article
Identification and characterization of the vesicular GABA transporter.
Nature - 23 Oct 1997
McIntire S L, Reimer R J, Schuske K, Edwards R H, Jorgensen E M
Abstract excerpt
Synaptic transmission involves the regulated exocytosis of vesicles filled with neurotransmitter. Classical transmitters are synthesized in the cytoplasm, and so must be transported into synaptic vesicles. Although the vesicular transporters for monoamines and acetylcholine have been identified, the proteins responsible for packaging the primary inhibitory and excitatory transmitters, gamma-aminobutyric acid...
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