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Article

Mutations in synaptojanin disrupt synaptic vesicle recycling.

The Journal of cell biology - 7 Aug 2000

Harris T W, Hartwieg E, Horvitz H R, Jorgensen E M

Abstract excerpt

Synaptojanin is a polyphosphoinositide phosphatase that is found at synapses and binds to proteins implicated in endocytosis. For these reasons, it has been proposed that synaptojanin is involved in the recycling of synaptic vesicles. Here, we demonstrate that the unc-26 gene encodes the Caenorhabditis elegans ortholog of synaptojanin. unc-26 mutants exhibit defects in vesicle trafficking in several tissues, but...

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Identifiers

PMID: 10931870
DOI: 10.1083/jcb.150.3.589
PMCID: PMC2175188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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