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Article

Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization.

Circulation research - 20 Jul 2007

Phillips Helen M, Rhee Hong Jun, Murdoch Jennifer N, Hildreth Victoria, Peat Jonathan D, Anderson Robert H, Copp Andrew J, Chaudhry Bill, Henderson Deborah J

Abstract excerpt

The Drosophila scribble gene regulates apical-basal polarity and is implicated in control of cellular architecture and cell growth control. Mutations in mammalian Scrib (circletail; Crc mutant) also result in abnormalities suggestive of roles in planar cell polarity regulation. We show that Crc mutants develop heart malformations and cardiomyopathy attributable to abnormalities in cardiomyocyte organization...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

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Source

Identifiers

PMID: 17556662
DOI: 10.1161/CIRCRESAHA.106.142406

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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