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Article

Rac1 Signaling Is Critical to Cardiomyocyte Polarity and Embryonic Heart Development

16 Sept 2014

Abstract excerpt

BACKGROUND: Defects in cardiac septation are the most common form of congenital heart disease, but the mechanisms underlying these defects are still poorly understood. The small GTPase Rac1 is implicated in planar cell polarity of epithelial cells in Drosophila; however, its role in mammalian cardiomyocyte polarity is not clear. We tested the hypothesis that Rac1 signaling in the second heart field regulates...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 25315346
DOI: 10.1161/jaha.114.001271

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