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Article

Vangl2-regulated polarisation of second heart field-derived cells is required for outflow tract lengthening during cardiac development.

PLoS genetics - 1 Dec 2014

Ramsbottom Simon A, Sharma Vipul, Rhee Hong Jun, Eley Lorraine, Phillips Helen M, Rigby Hannah F, Dean Charlotte, Chaudhry Bill, Henderson Deborah J

Abstract excerpt

Planar cell polarity (PCP) is the mechanism by which cells orient themselves in the plane of an epithelium or during directed cell migration, and is regulated by a highly conserved signalling pathway. Mutations in the PCP gene Vangl2, as well as in other key components of the pathway, cause a spectrum of cardiac outflow tract defects. However, it is unclear why cells within the mesodermal heart tissue require PCP...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25521757
DOI: 10.1371/journal.pgen.1004871
PMCID: PMC4270488

Genes

SHF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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