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Article

Structural basis of the human Scribble-Vangl2 association in health and disease.

The Biochemical journal - 16 Apr 2021

How Jing Yuan, Stephens Rebecca K, Lim Krystle Y B, Humbert Patrick O, Kvansakul Marc

Abstract excerpt

Scribble is a critical cell polarity regulator that has been shown to work as either an oncogene or tumor suppressor in a context dependent manner, and also impacts cell migration, tissue architecture and immunity. Mutations in Scribble lead to neural tube defects in mice and humans, which has been attributed to a loss of interaction with the planar cell polarity regulator Vangl2. We show that the Scribble PDZ...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33684218
DOI: 10.1042/BCJ20200816
PMCID: PMC8038854

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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