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Article

Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b.

Development (Cambridge, England) - 1 Apr 2010

Wansleeben Carolien, Feitsma Harma, Montcouquiol Mireille, Kroon Carla, Cuppen Edwin, Meijlink Frits

Abstract excerpt

Among the cellular properties that are essential for the organization of tissues during animal development, the importance of cell polarity in the plane of epithelial sheets has become increasingly clear in the past decades. Planar cell polarity (PCP) signaling in vertebrates has indispensable roles in many aspects of their development, in particular, controlling alignment of various types of epithelial cells....

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Identifiers

PMID: 20215345
DOI: 10.1242/dev.041434

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Planar cell polarity defects and defective Vangl2 trafficking in mutants for the COPII gene Sec24b.PMID 20215345Read ↗

Mutations in the COPII vesicle component gene SEC24B are associated with human neural tube defects.Semantic proximity Read ↗

Scribble1 plays an important role in the pathogenesis of neural tube defects through its mediating effect of Par-3 and Vangl1/2 localization.Semantic proximity Read ↗

Mutations in the planar cell polarity genes CELSR1 and SCRIB are associated with the severe neural tube defect craniorachischisis.Semantic proximity Read ↗

Planar cell polarity in the inner ear.Semantic proximity Read ↗

Identification of Vangl2 and Scrb1 as planar polarity genes in mammals.Semantic proximity Read ↗

Disruption of planar cell polarity signaling results in congenital heart defects and cardiomyopathy attributable to early cardiomyocyte disorganization.Semantic proximity Read ↗

Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates.Semantic proximity Read ↗

Sec24D-Dependent Transport of Extracellular Matrix Proteins Is Required for Zebrafish Skeletal MorphogenesisSemantic proximity Read ↗

Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.Semantic proximity Read ↗

Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice.Semantic proximity Read ↗

Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochleaSemantic proximity Read ↗

Secretory COPII coat component Sec23a is essential for craniofacial chondrocyte maturation.Semantic proximity Read ↗

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