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Article

Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.

Mammalian genome : official journal of the International Mammalian Genome Society - 1 Apr 2018

El-Hassan Abdul-Rahman, Leung Vicki, Kharfallah Fares, Guyot Marie-Claude, Allache Redouane, Gros Philippe, Kibar Zoha

Abstract excerpt

Planar cell polarity (PCP) signaling controls a number of morphogenetic processes including convergent extension during gastrulation and neural tube formation. Defects in this pathway cause neural tube defects (NTD), the most common malformations of the central nervous system. The Looptail (Lp) mutant mouse was the first mammalian mutant implicating a PCP gene (Vangl2) in the pathogenesis of NTD. We report on a...

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Source

Identifiers

PMID: 29063958
DOI: 10.1007/s00335-017-9721-8

Genes

DVL3

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Identification and characterization of a novel chemically induced allele at the planar cell polarity gene Vangl2.PMID 29063958Read ↗

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