Article

Structural basis of the human Scribble-Vangl2 association in health and disease

2020-10-08

Abstract excerpt

Scribble is a critical cell polarity regulator that has been shown to work as either an oncogene or tumor suppressor in a context dependent manner, and also impacts cell migration, tissue architecture and immunity. Mutations in Scribble lead to neural tube defects in mice and humans, which has been attributed to a loss of interaction with the planar cell polarity regulator Vangl2. We show that the Scribble PDZ dom...

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Literature Corpus work: 8d1bb9a7-73d6-54fa-8f13-befc4dc274fd
DOI: 10.1101/2020.10.07.330712

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