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Article

Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice.

Disease models & mechanisms - 1 Oct 2014

Murdoch Jennifer N, Damrau Christine, Paudyal Anju, Bogani Debora, Wells Sara, Greene Nicholas D E, Stanier Philip, Copp Andrew J

Abstract excerpt

Neural tube defects (NTDs) are among the commonest and most severe forms of developmental defect, characterized by disruption of the early embryonic events of central nervous system formation. NTDs have long been known to exhibit a strong genetic dependence, yet the identity of the genetic determinants remains largely undiscovered. Initiation of neural tube closure is disrupted in mice homozygous for mutations in...

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Identifiers

PMID: 25128525
DOI: 10.1242/dmm.016758
PMCID: PMC4174526

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice.PMID 25128525Read ↗

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